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These results suggest that overall the p16 ink4a gene is more responsible in inducing cellular senescence and tumor suppression in human cells interestingly the ink4aarf locus is known to be repressed by the polycomb proteins b lymphoma momlv insertion region 1 bmi1 and related family members in both human and mouse cellscellular senescence and tumor suppression it is now clear that cellular senescence is a crucial anticancer mechanism that prevents the growth of cells at risk for neoplastic transformation the stimuli that elicit a senescence response all have the potential to initiate or promote carcinogenesiscellular senescence and tumor suppression collects a number of chapters from leaders in the field to review the molecular basis of senescence and its physiological functions with a particular emphasis on the role of senescence in tumor suppression keywordscellular senescence and tumor suppression collects a number of chapters from leaders in the field to review the molecular basis of senescence and its physiological functions with a particular emphasis on the role of senescence in tumor suppression show all table of contents 10 chaptersget this from a library cellular senescence and tumor suppression peter d adams john m sedivy leonard hayflick and colleagues coined the term cellular senescence to describe the inevitable and irreversible proliferation arrest of primary human cells in culture specifically hayflick and

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